SPRAVATO®

Ketamine Nasal Spray For Depression

Covered By Most Insurances

Results as Early As 24 Hours*

Long Term Safety & Safety (up to 5 years)

FDA Approved For Treatment Resistant Depression

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TMS Therapy:

Advanced, Non-Invasive

Depression Treatment

Covered By Most Insurances

Completely Medication Free

FDA Cleared Treatment

4.8 Million Treatments Administered*

83% of Patients See Improvement*

62% of Patients See Full Remission*

Cleared for MDD & OCD

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You’re Covered

SPRAVATO® Is Covered by Most Insurances

Below are some of the most common ones we accept. Don't see yours? Contact us to see if your insurance covers SPRAVATO® .

What is SPRAVATO®?

SPRAVATO® (esketamine) is an FDA-approved nasal spray for adults with treatment-resistant depression or major depression with suicidal thoughts. It is a form of esketamine, which is chemically related to ketamine, but specially developed and approved for use in depression. SPRAVATO® is given in-clinic only, under supervision, and always paired with an oral antidepressant. After each session, patients stay for about 2 hours of monitoring to ensure safety.

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SPRAVATO®

Innovative Treatment for Difficult-to-Treat Depression

If you’ve tried multiple antidepressants without finding lasting relief, you may feel like you’ve run out of options.

At American Behavioral Clinics, we understand how discouraging that can be — and we’re here to help.

Our clinics are proud to offer esketamine nasal spray therapy, an FDA-approved option for adults with treatment-resistant depression (TRD) or major depressive disorder (MDD) with suicidal thoughts or actions.

FDA Approved
Covered By Insurance
Lead by Board Certified Psychiatric Professionals
Effective for Medication-Resistant Depression

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How Does SPRAVATO® Work?

SPRAVATO® (esketamine) works differently than traditional antidepressants. Instead of focusing on serotonin or dopamine, it targets the brain’s glutamate system, which plays a key role in mood and thought patterns. By acting on these pathways, SPRAVATO® may help restore connections in the brain and provide relief for some people who haven’t responded to other treatments.

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In 3 Simple Steps

Consultation & Welcome

Talk with one of our providers to see if esketamine (SPRAVATO®) therapy may be right for you. If approved, you’ll come to one of our comfortable treatment rooms where our staff will guide you through the process.

In-Clinic Administration

You’ll self-administer the SPRAVATO® nasal spray under direct supervision. Each session includes about 2 hours of monitoring for your safety, so you can relax while our team keeps you comfortable and supported.

Continue Care As Needed Directed

Ongoing sessions are scheduled based on your provider’s recommendation. SPRAVATO® is always paired with an oral antidepressant and is one part of a personalized treatment plan designed around your needs

Frequently Asked Questions

What is SPRAVATO®?

SPRAVATO® (esketamine) is an FDA-approved nasal spray used in adults with treatment-resistant depression or major depressive disorder with suicidal thoughts or actions.

Is this a clinical trial or a paid study?

No. SPRAVATO® is not experimental. It is an FDA-approved treatment offered in certified clinics like American Behavioral Clinics.

How does SPRAVATO® work?

SPRAVATO® targets the brain’s glutamate system, which is different from how most antidepressants work. This may help restore connections in the brain that affect mood and thought patterns.

Who qualifies for SPRAVATO® treatment?

It may be an option for adults who have tried at least two different antidepressants without success, or for adults experiencing major depression with suicidal thoughts. A provider must evaluate you to confirm eligibility.

Is SPRAVATO® the same as ketamine therapy?

SPRAVATO® contains esketamine, which is chemically related to ketamine but specifically developed, tested, and FDA-approved for depression treatment.

How is SPRAVATO® administered?

SPRAVATO® is a nasal spray that you self-administer in the clinic under direct supervision. You then stay for at least two hours of monitoring to ensure your safety.

How often will I need treatments?

Treatment frequency varies. Typically, it starts twice a week for the first month, then may reduce to once a week or every other week depending on your progress.

Can I drive myself home after a session?

No. Because SPRAVATO® may cause drowsiness, dissociation, or dizziness, you cannot drive until the next day after a treatment. Please arrange a ride home.

What are the common side effects?

Some patients may experience dizziness, nausea, sedation, or temporary changes in perception. Your provider will review all possible risks before you begin treatment.

Will insurance cover SPRAVATO®?

Many insurance plans, including Medicare and some Medicaid programs, may cover SPRAVATO®. Our team can help verify your benefits and discuss financial assistance options.

How soon can I expect results?

Some patients notice improvement within the first treatment, while others take longer. Results vary, and ongoing treatment is often needed to maintain progress.